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Target
E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM43476
Substrate
n/a
Meas. Tech.
E3 Ligase_WT_Dose Response
EC50
1060±n/a nM
Citation
 PubChem, PC E3 Ligase_WT_Dose Response PubChem Bioassay (2008)[AID] 
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
  
Inhibitor
Name:
BDBM43476
Synonyms:
1-methyl-4-[(2,3,4,5-tetrachloro-1-cyclopenta-2,4-dienylidene)methyl]benzene | 1-methyl-4-[(2,3,4,5-tetrachlorocyclopenta-2,4-dien-1-ylidene)methyl]benzene | 1-methyl-4-[[2,3,4,5-tetrakis(chloranyl)cyclopenta-2,4-dien-1-ylidene]methyl]benzene | MLS000738051 | SMR000393724 | cid_230812
Type:
Small organic molecule
Emp. Form.:
C13H8Cl4
Mol. Mass.:
306.015
SMILES:
[#6]-c1ccc(\[#6]=[#6]-2\[#6](Cl)=[#6](Cl)-[#6](Cl)=[#6]-2Cl)cc1 |c:12,t:8|
Structure:
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