Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1 [S99G]
Ligand
BDBM38875
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)
IC50
1420±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay (2008)[AID] 
Target
Name:
Neutrophil cytosol factor 1 [S99G]
Synonyms:
NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44664.39
Organism:
Homo sapiens (Human)
Description:
gi_115298672
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM38875
Synonyms:
2-(5-spiro[3H-benzimidazole-2,1'-cyclohexane]ylidene)propanedinitrile | 2-spiro[3H-benzimidazole-2,1'-cyclohexane]-5-ylidenemalononitrile | 2-spiro[3H-benzimidazole-2,1'-cyclohexane]-5-ylidenepropanedinitrile | MLS000038588 | SMR000038412 | cid_657611
Type:
Small organic molecule
Emp. Form.:
C15H14N4
Mol. Mass.:
250.2985
SMILES:
N#CC(C#N)=c1ccc2=NC3(CCCCC3)Nc2c1 |t:8,(7.69,6.11,;6.92,4.78,;6.16,3.44,;4.62,3.43,;3.08,3.43,;6.94,2.11,;8.54,2.11,;9.33,.71,;8.51,-.66,;8.98,-2.13,;7.74,-3.03,;9.07,-3.8,;9.07,-5.34,;7.74,-6.11,;6.4,-5.34,;6.4,-3.8,;6.49,-2.13,;6.97,-.66,;6.14,.71,)|
Structure:
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