Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1 [S99G]
Ligand
BDBM55391
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)
IC50
5280±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay (2008)[AID] 
Target
Name:
Neutrophil cytosol factor 1 [S99G]
Synonyms:
NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44664.39
Organism:
Homo sapiens (Human)
Description:
gi_115298672
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM55391
Synonyms:
1-[3-[1,1-bis(4-methoxyphenyl)but-1-en-2-yl]-1-indolyl]-3-(4-methyl-1-piperazinyl)-2-propanol | 1-[3-[1,1-bis(4-methoxyphenyl)but-1-en-2-yl]indol-1-yl]-3-(4-methylpiperazin-1-yl)propan-2-ol | 1-[3-[1-ethyl-2,2-bis(4-methoxyphenyl)vinyl]indol-1-yl]-3-(4-methylpiperazino)propan-2-ol | 1-{3-[1-ethyl-2,2-bis(4-methoxyphenyl)vinyl]-1H-indol-1-yl}-3-(4-methyl-1-piperazinyl)-2-propanol | MLS000533166 | SMR000140604 | cid_2859666
Type:
Small organic molecule
Emp. Form.:
C34H41N3O3
Mol. Mass.:
539.7076
SMILES:
[#6]-[#6]\[#6](=[#6](/c1ccc(-[#8]-[#6])cc1)-c1ccc(-[#8]-[#6])cc1)-c1cn(-[#6]-[#6](-[#8])-[#6]-[#7]-2-[#6]-[#6]-[#7](-[#6])-[#6]-[#6]-2)c2ccccc12
Structure:
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