Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1 [S99G]
Ligand
BDBM47847
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)
IC50
50000±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay (2008)[AID] 
Target
Name:
Neutrophil cytosol factor 1 [S99G]
Synonyms:
NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44664.39
Organism:
Homo sapiens (Human)
Description:
gi_115298672
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM47847
Synonyms:
2-(6-Fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-1-(8-methyl-1,3,4,5-tetrahydro-pyrido[4,3-b]indol-2-yl )-ethanone | 2-(6-fluoranyl-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-1-(8-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)ethanone | 2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-1-(8-methyl-1,3,4,5-tetrahydropyrid[4,3-b]indol-2-yl)ethanone | 2-(6-fluoro-2-methyl-3,4-dihydro-2H-quinolin-1-yl)-1-(8-methyl-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl)ethanone | MLS000557006 | SMR000148123 | cid_4371580
Type:
Small organic molecule
Emp. Form.:
C24H26FN3O
Mol. Mass.:
391.4811
SMILES:
CC1CCc2cc(F)ccc2N1CC(=O)N1CCc2[nH]c3ccc(C)cc3c2C1
Structure:
Search PDB for entries with ligand similarity: