Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1 [S99G]
Ligand
BDBM55680
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)
IC50
4420±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay (2008)[AID] 
Target
Name:
Neutrophil cytosol factor 1 [S99G]
Synonyms:
NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44664.39
Organism:
Homo sapiens (Human)
Description:
gi_115298672
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM55680
Synonyms:
4-[(E)-[4-(3-chlorobenzyl)-3-keto-1,4-benzothiazin-2-ylidene]methyl]-N-[3-(4-methylpiperazino)propyl]benzamide | 4-[(E)-[4-[(3-chlorophenyl)methyl]-3-oxidanylidene-1,4-benzothiazin-2-ylidene]methyl]-N-[3-(4-methylpiperazin-1-yl)propyl]benzamide | 4-[(E)-[4-[(3-chlorophenyl)methyl]-3-oxo-1,4-benzothiazin-2-ylidene]methyl]-N-[3-(4-methyl-1-piperazinyl)propyl]benzamide | 4-[(E)-[4-[(3-chlorophenyl)methyl]-3-oxo-1,4-benzothiazin-2-ylidene]methyl]-N-[3-(4-methylpiperazin-1-yl)propyl]benzamide | 4-{(E)-[4-(3-chlorobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-ylidene]methyl}-N-[3-(4-methylpiperazin-1-yl)propyl]benzamide | MLS000682565 | SMR000311922 | cid_16187656
Type:
Small organic molecule
Emp. Form.:
C31H33ClN4O2S
Mol. Mass.:
561.137
SMILES:
CN1CCN(CCCNC(=O)c2ccc(\C=C3\Sc4ccccc4N(Cc4cccc(Cl)c4)C3=O)cc2)CC1
Structure:
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