Reaction Details Report a problem with these data
Target
Neutrophil cytosol factor 1 [S99G]
Ligand
BDBM52827
Substrate
n/a
Meas. Tech.
Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)
IC50
390±n/a nM
Citation
 PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay (2008)[AID] 
Target
Name:
Neutrophil cytosol factor 1 [S99G]
Synonyms:
NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44664.39
Organism:
Homo sapiens (Human)
Description:
gi_115298672
Residue:
390
Sequence:
MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPIEAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKVRPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQPAVPPRPSADLILNRCSESTKRKLASAV
  
Inhibitor
Name:
BDBM52827
Synonyms:
(7-amino-8-methyl-3-phenothiazinylidene)-dimethylammonium;hydrochloride | (7-amino-8-methyl-phenothiazin-3-ylidene)-dimethyl-ammonium;hydrochloride | (7-amino-8-methylphenothiazin-3-ylidene)-dimethylazanium;hydrochloride | (7-azanyl-8-methyl-phenothiazin-3-ylidene)-dimethyl-azanium;hydrochloride | MLS000738130 | SMR000393892 | cid_16682403
Type:
Small organic molecule
Emp. Form.:
C15H16N3S
Mol. Mass.:
270.372
SMILES:
Cc1cc2nc3ccc(cc3sc2cc1N)=[N+](C)C |(12.52,4.7,;11.24,5.45,;9.9,4.69,;8.58,5.48,;7.3,4.74,;6.02,5.48,;4.7,4.69,;3.36,5.45,;3.36,6.99,;4.7,7.75,;6.02,6.96,;7.3,7.69,;8.58,6.96,;9.9,7.75,;11.24,6.99,;12.52,7.73,;2.08,7.73,;.8,7,;2.08,9.21,)|
Structure:
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