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Target
Caspase-3
Ligand
BDBM63168
Substrate
n/a
Meas. Tech.
Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3
EC50
>85267±n/a nM
Citation
 PubChem, PC Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3 PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM63168
Synonyms:
4-methyl-2-[[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]amino]-5-(phenylmethyl)thiophene-3-carboxamide | 4-methyl-2-[[(Z)-(2-oxo-1-naphthalenylidene)methyl]amino]-5-(phenylmethyl)-3-thiophenecarboxamide | 5-Benzyl-2-[(2-hydroxy-naphthalen-1-ylmethylene)-amino]-4-methyl-thiophene-3-carboxylic acid amide | 5-benzyl-2-[[(Z)-(2-keto-1-naphthylidene)methyl]amino]-4-methyl-thiophene-3-carboxamide | 5-benzyl-4-methyl-2-[[(Z)-(2-oxonaphthalen-1-ylidene)methyl]amino]thiophene-3-carboxamide | MLS000555066 | SMR000171736 | cid_5432072
Type:
Small organic molecule
Emp. Form.:
C24H20N2O2S
Mol. Mass.:
400.493
SMILES:
Cc1c(Cc2ccccc2)sc(N=Cc2c(O)ccc3ccccc23)c1C(N)=O |w:12.12|
Structure:
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