Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM404336
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
43.6±n/a nM
Citation
 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N; Yu, T Piperidine isoxazole and isothiazole orexin receptor antagonists US Patent  US10017504 Publication Date 7/10/2018 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM404336
Synonyms:
Methyl 2-({(2R,5R)-5-[5-(1-hydroxy-1- methylethyl)isothiazol-3-yl]-2- methylpiperidin-1-yl}carbonyl)benzoate | US10017504, 67
Type:
Small organic molecule
Emp. Form.:
C20H25N3O4S
Mol. Mass.:
403.495
SMILES:
COC(=O)c1ncccc1C(=O)N1C[C@@H](CC[C@H]1C)c1cc(sn1)C(C)(C)O
Structure:
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