Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM81922
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±0
Temperature
298.15±0 K
Ki
312±0.0 nM
Citation
 Carta, F; Pothen, B; Maresca, A; Tiwari, M; Singh, V; Supuran, CT Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes. Chem Biol Drug Des 74:196-202 (2009) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM81922
Synonyms:
p-Phenyldiazenyl derivative, 7
Type:
Small organic molecule
Emp. Form.:
C14H15N3O3S
Mol. Mass.:
305.352
SMILES:
CN(C)S(=O)(=O)c1ccc(cc1)N=Nc1ccc(O)cc1 |w:12.12|
Structure:
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