Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83466
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83466
Synonyms:
MLS000068342 | N-(3-Cyano-4,5-dimethyl-thiophen-2-yl)-2-(3-tetrazol-1-yl-phenoxy)-acetamide | N-(3-cyano-4,5-dimethyl-2-thienyl)-2-[3-(tetrazol-1-yl)phenoxy]acetamide | N-(3-cyano-4,5-dimethyl-2-thiophenyl)-2-[3-(1-tetrazolyl)phenoxy]acetamide | N-(3-cyano-4,5-dimethyl-thiophen-2-yl)-2-[3-(1,2,3,4-tetrazol-1-yl)phenoxy]ethanamide | N-(3-cyano-4,5-dimethylthiophen-2-yl)-2-[3-(tetrazol-1-yl)phenoxy]acetamide | SMR000002020 | cid_647106
Type:
Small organic molecule
Emp. Form.:
C16H14N6O2S
Mol. Mass.:
354.386
SMILES:
Cc1sc(NC(=O)COc2cccc(c2)-n2cnnn2)c(C#N)c1C
Structure:
Search PDB for entries with ligand similarity: