Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM29614
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM29614
Synonyms:
6-methoxy-2-(1-pyrrolidinyl)-3-quinolinecarbonitrile | 6-methoxy-2-pyrrolidin-1-yl-quinoline-3-carbonitrile | 6-methoxy-2-pyrrolidin-1-ylquinoline-3-carbonitrile | 6-methoxy-2-pyrrolidino-quinoline-3-carbonitrile | MLS000070501 | SMR000001680 | cid_649963
Type:
Small organic molecule
Emp. Form.:
C15H15N3O
Mol. Mass.:
253.2991
SMILES:
COc1ccc2nc(N3CCCC3)c(cc2c1)C#N
Structure:
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