Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM44437
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
84000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM44437
Synonyms:
1-ethyl-3-phenyl-pyrazolo[4,3-b]quinoxaline | 1-ethyl-3-phenylpyrazolo[4,3-b]quinoxaline | MLS000041625 | SMR000046273 | cid_665240
Type:
Small organic molecule
Emp. Form.:
C17H14N4
Mol. Mass.:
274.3199
SMILES:
CCn1nc(-c2ccccc2)c2nc3ccccc3nc12
Structure:
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