Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83483
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83483
Synonyms:
1'-acetyl-4,7-dibutoxy-1,3-dihydrospiro[benzimidazole-2,3'-indol]-2'(1'H)-one | 1'-acetyl-4,7-dibutoxy-2'-spiro[1,3-dihydrobenzimidazole-2,3'-indole]one | 1'-acetyl-4,7-dibutoxy-spiro[1,3-dihydrobenzimidazole-2,3'-indoline]-2'-one | 1'-acetyl-4,7-dibutoxyspiro[1,3-dihydrobenzimidazole-2,3'-indole]-2'-one | 4,7-dibutoxy-1'-ethanoyl-spiro[1,3-dihydrobenzimidazole-2,3'-indole]-2'-one | MLS000084636 | SMR000018984 | cid_3239485
Type:
Small organic molecule
Emp. Form.:
C24H29N3O4
Mol. Mass.:
423.5048
SMILES:
CCCCOc1ccc(OCCCC)c2NC3(Nc12)C(=O)N(C(C)=O)c1ccccc31
Structure:
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