Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM84512
Substrate
n/a
Meas. Tech.
Phosphatase Inhibition Assay
pH
6.5±0
Temperature
310.15±0 K
IC50
2.1e+4± 1.2e+4 nM
Citation
 Fürstner, A; Reinecke, K; Prinz, H; Waldmann, H The core structures of roseophilin and the prodigiosin alkaloids define a new class of protein tyrosine phosphatase inhibitors. Chembiochem 5:1575-9 (2004) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM84512
Synonyms:
Acyclic analogue, 18
Type:
Small organic molecule
Emp. Form.:
C21H28N2O4
Mol. Mass.:
372.458
SMILES:
COC1=CC(=O)N\C1=C/c1ccc(CCCC\C=C\CCCCC(O)=O)[nH]1 |t:2|
Structure:
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