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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50000594
Substrate
n/a
Meas. Tech.
ChEMBL_201751 (CHEMBL809885)
IC50
99±n/a nM
Citation
 Erickson, RH; Natalie, KJ; Bock, W; Lu, Z; Farzin, F; Sherrill, RG; Meloni, DJ; Patch, RJ; Rzesotarski, WJ; Clifton, J (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem 35:1526-35 (1992) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50000594
Synonyms:
6-[6-(4-Hydroxy-piperidin-1-yl)-hex-4-enyloxy]-3-methyl-2-phenyl-chromen-4-one | CHEMBL440606
Type:
Small organic molecule
Emp. Form.:
C27H31NO4
Mol. Mass.:
433.5393
SMILES:
Cc1c(oc2ccc(OCCC\C=C\CN3CCC(O)CC3)cc2c1=O)-c1ccccc1
Structure:
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