Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50000622
Substrate
n/a
Meas. Tech.
ChEMBL_201751 (CHEMBL809885)
IC50
60±n/a nM
Citation
 Erickson, RH; Natalie, KJ; Bock, W; Lu, Z; Farzin, F; Sherrill, RG; Meloni, DJ; Patch, RJ; Rzesotarski, WJ; Clifton, J (Aminoalkoxy)chromones. Selective sigma receptor ligands. J Med Chem 35:1526-35 (1992) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50000622
Synonyms:
2-(2-Chloro-phenyl)-6-(6-piperidin-1-yl-hexyloxy)-chromen-4-one | CHEMBL37138
Type:
Small organic molecule
Emp. Form.:
C26H30ClNO3
Mol. Mass.:
439.974
SMILES:
Clc1ccccc1-c1cc(=O)c2cc(OCCCCCCN3CCCCC3)ccc2o1
Structure:
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