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Target
Protein mono-ADP-ribosyltransferase PARP12
Ligand
BDBM50242630
Substrate
n/a
Meas. Tech.
ChEMBL_1672039 (CHEMBL4022068)
IC50
8200±n/a nM
Citation
 Upton, K; Meyers, M; Thorsell, AG; Karlberg, T; Holechek, J; Lease, R; Schey, G; Wolf, E; Lucente, A; Schüler, H; Ferraris, D Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14. Bioorg Med Chem Lett 27:2907-2911 (2017) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP12
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 12 | ARTD12 | PAR12_HUMAN | PARP-12 | PARP12 | Poly [ADP-ribose] polymerase 12 | ZC3HDC1 | Zinc finger CCCH domain-containing protein 1
Type:
PROTEIN
Mol. Mass.:
79092.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107665
Residue:
701
Sequence:
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAAAPERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
  
Inhibitor
Name:
BDBM50242630
Synonyms:
CHEMBL4089522
Type:
Small organic molecule
Emp. Form.:
C21H21FN4O3
Mol. Mass.:
396.4148
SMILES:
NC(=O)c1cccc(NC(=O)\C=C/C(=O)N2CCN(CC2)c2ccc(F)cc2)c1
Structure:
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