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Target
Beta-lactamase OXA-10
Ligand
BDBM50247467
Substrate
n/a
Meas. Tech.
ChEMBL_1677807 (CHEMBL4027950)
IC50
37300±n/a nM
Citation
 Cain, R; Brem, J; Zollman, D; McDonough, MA; Johnson, RM; Spencer, J; Makena, A; Abboud, MI; Cahill, S; Lee, SY; McHugh, PJ; Schofield, CJ; Fishwick, CWG In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-?-lactamase Inhibitors. J Med Chem 61:1255-1260 (2018) [PubMed]  Article 
Target
Name:
Beta-lactamase OXA-10
Synonyms:
BLO10_PSEAI | bla | oxa10 | pse2
Type:
PROTEIN
Mol. Mass.:
29508.45
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_571868
Residue:
266
Sequence:
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
  
Inhibitor
Name:
BDBM50247467
Synonyms:
CHEMBL4083640
Type:
Small organic molecule
Emp. Form.:
C14H10Cl2O2S
Mol. Mass.:
313.199
SMILES:
OC(=O)c1ccc(cc1CS)-c1cccc(Cl)c1Cl
Structure:
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