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Target
Histamine H1 receptor
Ligand
BDBM50007538
Substrate
n/a
Meas. Tech.
ChEMBL_83772 (CHEMBL693830)
IC50
0.260000±n/a nM
Citation
 Sleevi, MC; Cale, AD; Gero, TW; Jaques, LW; Welstead, WJ; Johnson, AF; Kilpatrick, BF; Demian, I; Nolan, JC; Jenkins, H Optical isomers of rocastine and close analogues: synthesis and H1 antihistaminic activity of its enantiomers and their structural relationship to the classical antihistamines. J Med Chem 34:1314-28 (1991) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50007538
Synonyms:
8-(2-Azetidin-1-yl-ethyl)-3-chloro-6-methyl-7,8-dihydro-6H-9-oxa-1,6-diaza-benzocycloheptene-5-thione | CHEMBL25626
Type:
Small organic molecule
Emp. Form.:
C14H18ClN3OS
Mol. Mass.:
311.83
SMILES:
CN1C[C@@H](CCN2CCC2)Oc2ncc(Cl)cc2C1=S
Structure:
Search PDB for entries with ligand similarity: