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Found 156 with Last Name = 'jenkins' and Initial = 'h'
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104526(3-[2-((S)-3-Methyl-1-{2-[4-(3-o-tolyl-ureido)-phen...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of human recombinant sVCAM-1 binding to alpha4-beta1 integrin (VLA-4) in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50007538(8-(2-Azetidin-1-yl-ethyl)-3-chloro-6-methyl-7,8-di...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104531(3-[3-((S)-1-{2-[3-Methoxy-4-(3-o-tolyl-ureido)-phe...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of Alpha4-beta1 integrin in Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  0.800nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104531(3-[3-((S)-1-{2-[3-Methoxy-4-(3-o-tolyl-ureido)-phe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Alpha4-beta1 integrin in Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  1.60nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50007542(3-Chloro-8-(2-dimethylamino-ethyl)-6-methyl-7,8-di...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062387(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062387(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Affinity DataIC50:  2.20nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104529((S)-1-{2-[(S)-(R)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human recombinant sVCAM-1 binding to alpha4-beta1 integrin (VLA-4) in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062387(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Affinity DataIC50:  2.70nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104530(3-[2-((S)-3-Methyl-1-{2-[4-(3-o-tolyl-ureido)-phen...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant sVCAM-1 binding to alpha4-beta1 integrin (VLA-4) in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50061977(17,25-diazonia-2,9-diazaheptacyclo[23.6.2.24,7.210...)
Affinity DataIC50:  3nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  3.80nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104529((S)-1-{2-[(S)-(R)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of VCAM binding to Alpha4-beta1 integrin of human eosinophil cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202531(9-cyclopentyl-5,6-dihydro-7-ethyl-3-(tert-butyl)-9...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104533(3-[5-(2-Carboxy-ethyl)-3-((S)-3-methyl-1-{2-[4-(3-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Alpha4-beta1 integrin in Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM35938(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202531(9-cyclopentyl-5,6-dihydro-7-ethyl-3-(tert-butyl)-9...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104536((R)-3-(2,6-Dichloro-benzoylamino)-4-(2',6'-dimetho...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of Alpha4-beta1 integrin in Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062381(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-methyl-4,5...)
Affinity DataIC50:  9.80nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104531(3-[3-((S)-1-{2-[3-Methoxy-4-(3-o-tolyl-ureido)-phe...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant sVCAM-1 binding to alpha4-beta1 integrin (VLA-4) in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062381(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-methyl-4,5...)
Affinity DataIC50:  10nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataIC50:  10.7nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062381(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-5-methyl-4,5...)
Affinity DataIC50:  10.9nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202531(9-cyclopentyl-5,6-dihydro-7-ethyl-3-(tert-butyl)-9...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202544(9-cyclopentyl-5,6-dihydro-7-ethyl-3-(2-chloropheny...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202528(8-Cyclopentyl-6-ethyl-3-thiophen-2-yl-5,8-dihydro-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202528(8-Cyclopentyl-6-ethyl-3-thiophen-2-yl-5,8-dihydro-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant PDE4CMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062383(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Affinity DataIC50:  15.3nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062383(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Affinity DataIC50:  15.6nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104526(3-[2-((S)-3-Methyl-1-{2-[4-(3-o-tolyl-ureido)-phen...)
Affinity DataIC50:  16nMAssay Description:Inhibition of VCAM binding to Alpha4-beta1 integrin of human eosinophil cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062383(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Affinity DataIC50:  17.9nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062387(3-(3-Cyclopentyloxy-4-methoxy-phenyl)-4,5-dihydro-...)
Affinity DataIC50:  18nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104527(3-[3-((S)-3-Methyl-1-{2-[4-(3-o-tolyl-ureido)-phen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of VCAM binding to Alpha4-beta1 integrin of human eosinophil cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202544(9-cyclopentyl-5,6-dihydro-7-ethyl-3-(2-chloropheny...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062379(3-Cyclopentyloxy-N-(1-hydroxycarbamoyl-ethyl)-4-me...)
Affinity DataIC50:  20.2nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062379(3-Cyclopentyloxy-N-(1-hydroxycarbamoyl-ethyl)-4-me...)
Affinity DataIC50:  22.2nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50202528(8-Cyclopentyl-6-ethyl-3-thiophen-2-yl-5,8-dihydro-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50007536(CHEMBL24517 | [3-(5-Chloro-pyridin-2-yl)-3-pyridin...)
Affinity DataIC50:  24nMAssay Description:Inhibition of [3H]-mepyramine binding to the Histamine H1 receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50473100(CHEMBL344807)
Affinity DataIC50:  25nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50104534(3-[3-((S)-3-Methyl-1-{2-[4-(3-o-tolyl-ureido)-phen...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant sVCAM-1 binding to alpha4-beta1 integrin (VLA-4) in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062383(3-Cyclopentyloxy-N-hydroxycarbamoylmethyl-4-methox...)
Affinity DataIC50:  27.2nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmall conductance calcium-activated potassium channel protein 1/2/3(Rattus norvegicus)
University College London

Curated by ChEMBL
LigandPNGBDBM50473103(CHEMBL430146)
Affinity DataIC50:  28nMAssay Description:The blocking of apamin-sensitive [Ca2+]-activated K+ (SKCa) channel was assessed by the compounds ability to inhibit the after-hyperpolarization in c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
A.H. Robins

Curated by ChEMBL
LigandPNGBDBM50007539(8-(2-Dimethylamino-ethyl)-6-methyl-7,8-dihydro-6H-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of [3H]-mepyramine binding to the histamine receptor in guinea pig cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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