Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50128581
Substrate
n/a
Meas. Tech.
ChEMBL_1687002 (CHEMBL4037481)
IC50
28000±n/a nM
Citation
Aghazadeh Tabrizi, M; Baraldi, PG; Baraldi, S; Ruggiero, E; De Stefano, L; Rizzolio, F; Di Cesare Mannelli, L; Ghelardini, C; Chicca, A; Lapillo, M; Gertsch, J; Manera, C; Macchia, M; Martinelli, A; Granchi, C; Minutolo, F; Tuccinardi, T Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. J Med Chem 61:1340-1354 (2018) [PubMed] Article
More Info.:
Target
Name:
Monoglyceride lipase
Synonyms:
MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL)
Type:
Enzyme
Mol. Mass.:
33505.38
Organism:
Rattus norvegicus (Rat)
Description:
Q8R431
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
Inhibitor
Name:
BDBM50128581
Synonyms:
Biphenyl-3-yl-carbamic acid cyclohexyl ester | CHEMBL77767 | URB602 | biphenyl-3-ylcarbamic acid cyclohexyl ester | cyclohexyl biphenyl-3-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C19H21NO2
Mol. Mass.:
295.3755
SMILES:
O=C(Nc1cccc(c1)-c1ccccc1)OC1CCCCC1