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Found 502 with Last Name = 'granchi' and Initial = 'c'
TargetEstrogen receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346462((E)-2-chloro-4,4'-dihydroxybiphenyl-3-carbaldehyde...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]estradiol from human full-length ERbeta receptor by competitive radiometric binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]estradiol from human full-length ERbeta receptor by competitive radiometric binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50574656(CHEMBL4866490)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant MAGL assessed as dissociation constant using 4-NPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50574654(CHEMBL4870906)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant MAGL assessed as dissociation constant using 4-NPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50574655(CHEMBL4852896)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant MAGL assessed as dissociation constant using 4-NPA as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50605682(CHEMBL5176915)
Affinity DataKi:  1.40nMAssay Description:Competitive inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate assessed as inhibition constant by Michaelis-Menten analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataKi:  4.80nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50255198((E)-3-Chloro-4-(3-fluoro-4-hydroxyphenyl)salicylal...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]estradiol from full-length human estrogen receptor beta by radiometric assay relative to estradiolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562160(CHEMBL4757403)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562158(CHEMBL4747585)
Affinity DataKi:  27nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562161(CHEMBL4755606)
Affinity DataKi:  30nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50562159(CHEMBL4798508)
Affinity DataKi:  37nMAssay Description:Competitive inhibition of human recombinant MAGL using varying concentration of 4-nitrophenylacetate as substrate incubated for 30 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50531972(CHEMBL4536045)
Affinity DataKi:  39nMAssay Description:Competitive inhibition of human recombinant MAGL using 4-NPA as substrate after 30 mins by Michaelis-Menten-based plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50066694((S)-2-[(R)-7-(3-Chloro-9H-fluoren-9-yl)-2-hydroxy-...)
Affinity DataKi:  220nMAssay Description:Inhibition of human ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50255235(CHEMBL4078924)
Affinity DataKi:  412nMAssay Description:Competitive inhibition of recombinant human MAGL using 4-NPA as substrate after 30 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50470454(CHEMBL4282040)
Affinity DataKi:  650nMAssay Description:Competitive inhibition of human recombinant MAGL using 4-NPA substrate incubated for 30 mins by Michaelis-Menten kinetics analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50394677(CHEMBL2165262)
Affinity DataKi:  700nMAssay Description:Competitive inhibition of human liver ACLY using varying levels of citrate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM26192(3,5-difluorophenol | phenol derivative, 6)
Affinity DataKi:  944nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of rat ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50053000(2-[8-(2,4-Dichloro-phenyl)-2-oxo-octyl]-2-hydroxy-...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346462((E)-2-chloro-4,4'-dihydroxybiphenyl-3-carbaldehyde...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50053001(2-[6-(2,4-Dichloro-phenyl)-hexylsulfanylmethyl]-su...)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50052989(2-[8-(2,4-Dichloro-phenyl)-octyl]-2-hydroxy-succin...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428445(CHEMBL272457)
Affinity DataKi:  3.14E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50394678(CHEMBL2165261)
Affinity DataKi:  3.20E+3nMAssay Description:Competitive inhibition of human liver ACLY using varying levels of citrate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50053020(2-[6-(2,4-Dichloro-phenyl)-hexylsulfanylmethyl]-2-...)
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428447(CHEMBL479638)
Affinity DataKi:  3.32E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428449(CHEMBL449451)
Affinity DataKi:  3.66E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataKi:  3.74E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoglycerate mutase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50103572(CHEMBL3335789)
Affinity DataKi:  3.91E+3nMAssay Description:Inhibition of PGM1 (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346462((E)-2-chloro-4,4'-dihydroxybiphenyl-3-carbaldehyde...)
Affinity DataKi:  3.98E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50469150(CHEMBL4287406)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50469151(CHEMBL4280177)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50469152(CHEMBL4290816)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50469149(CHEMBL4283629)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of rat liver ACLYMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428450(CHEMBL475278)
Affinity DataKi:  4.13E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428450(CHEMBL475278)
Affinity DataKi:  4.24E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346462((E)-2-chloro-4,4'-dihydroxybiphenyl-3-carbaldehyde...)
Affinity DataKi:  4.31E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428447(CHEMBL479638)
Affinity DataKi:  4.53E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50339607(1-Hydroxy-6-phenyl-4-trifluoromethyl-1H-indole-2-c...)
Affinity DataKi:  4.70E+3nMAssay Description:Competitive inhibition of human LDH-A using pyruvate as substrate after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428448(CHEMBL479836)
Affinity DataKi:  4.77E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428448(CHEMBL479836)
Affinity DataKi:  4.96E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50103570(CHEMBL3335796)
Affinity DataKi:  5.10E+3nMAssay Description:Inhibition of LDHA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346463((E)-2-chloro-3'-fluoro-4,4'-dihydroxybiphenyl-3-ca...)
Affinity DataKi:  5.53E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428445(CHEMBL272457)
Affinity DataKi:  5.87E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428449(CHEMBL449451)
Affinity DataKi:  5.94E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50346462((E)-2-chloro-4,4'-dihydroxybiphenyl-3-carbaldehyde...)
Affinity DataKi:  6.02E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428446(CHEMBL272458)
Affinity DataKi:  6.35E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50428446(CHEMBL272458)
Affinity DataKi:  6.43E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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