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Target
Monoglyceride lipase
Ligand
BDBM50255288
Substrate
n/a
Meas. Tech.
ChEBML_1687006
IC50
48000±n/a nM
Citation
 Aghazadeh Tabrizi, M; Baraldi, PG; Baraldi, S; Ruggiero, E; De Stefano, L; Rizzolio, F; Di Cesare Mannelli, L; Ghelardini, C; Chicca, A; Lapillo, M; Gertsch, J; Manera, C; Macchia, M; Martinelli, A; Granchi, C; Minutolo, F; Tuccinardi, T Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. J Med Chem 61:1340-1354 (2018) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50255288
Synonyms:
CHEMBL4075839
Type:
Small organic molecule
Emp. Form.:
C24H22N6O2
Mol. Mass.:
426.4705
SMILES:
Oc1cccc(c1)-c1cc(nn1-c1ccccc1)C(=O)N1CCN(CC1)c1ncccn1
Structure:
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