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Target
Vesicular acetylcholine transporter
Ligand
BDBM50260157
Substrate
n/a
Meas. Tech.
ChEBML_1692765
Ki
376±n/a nM
Citation
 Lindemann, M; Deuther-Conrad, W; Moldovan, R; Sekhar, KVGC; Brust, P; Wenzel, B Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter? Bioorg Med Chem 25:5107-5113 (2017) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
Slc18a3 | Solute carrier family 18 member 3 | VACHT_RAT | Vacht | Vat | rVAT
Type:
PROTEIN
Mol. Mass.:
56533.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1503353
Residue:
530
Sequence:
MEPTAPTGQARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGSEGPTLVSEVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLREVQGKDGGEPCSPPGPFDGCEDDYNYYSRS
  
Inhibitor
Name:
BDBM50260157
Synonyms:
CHEMBL4091414
Type:
Small organic molecule
Emp. Form.:
C27H24ClF2N3O
Mol. Mass.:
479.949
SMILES:
Fc1ccc2N(CC3(CCN(C\C=C\c4ccc(Cl)cc4)CC3)c2c1)C(=O)c1ccc(F)nc1
Structure:
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