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Target
Signal peptide peptidase-like 2A
Ligand
BDBM50263008
Substrate
n/a
Meas. Tech.
ChEBML_1697375
IC50
6.0±n/a nM
Citation
 Velcicky, J; Bodendorf, U; Rigollier, P; Epple, R; Beisner, DR; Guerini, D; Smith, P; Liu, B; Feifel, R; Wipfli, P; Aichholz, R; Couttet, P; Dix, I; Widmer, T; Wen, B; Brandl, T Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem 61:865-880 (2018) [PubMed]  Article 
Target
Name:
Signal peptide peptidase-like 2A
Synonyms:
3.4.23.- | IMP-3 | IMP3 | Intramembrane protease 3 | PSL2 | Presenilin-like protein 2 | SPP-like 2A | SPP2A_HUMAN | SPPL2A | Signal peptide peptidase-like 2A
Type:
PROTEIN
Mol. Mass.:
58152.61
Organism:
Homo sapiens
Description:
ChEMBL_117438
Residue:
520
Sequence:
MGPQRRLSPAGAALLWGFLLQLTAAQEAILHASGNGTTKDYCMLYNPYWTALPSTLENATSISLMNLTSTPLCNLSDIPPVGIKSKAVVVPWGSCHFLEKARIAQKGGAEAMLVVNNSVLFPPSGNRSEFPDVKILIAFISYKDFRDMNQTLGDNITVKMYSPSWPNFDYTMVVIFVIAVFTVALGGYWSGLVELENLKAVTTEDREMRKKKEEYLTFSPLTVVIFVVICCVMMVLLYFFYKWLVYVMIAIFCIASAMSLYNCLAALIHKIPYGQCTIACRGKNMEVRLIFLSGLCIAVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTLKLPNFKSCVILLGLLLLYDVFFVFITPFITKNGESIMVELAAGPFGNNEKLPVVIRVPKLIYFSVMSVCLMPVSILGFGDIIVPGLLIAYCRRFDVQTGSSYIYYVSSTVAYAIGMILTFVVLVLMKKGQPALLYLVPCTLITASVVAWRRKEMKKFWKGNSYQMMDHLDCATNEENPVISGEQIVQQ
  
Inhibitor
Name:
BDBM50263008
Synonyms:
CHEMBL255473
Type:
Small organic molecule
Emp. Form.:
C43H64N6O9
Mol. Mass.:
809.0031
SMILES:
CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1
Structure:
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