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Target
Dihydrofolate reductase
Ligand
BDBM50011889
Substrate
n/a
Meas. Tech.
ChEBML_54103
IC50
27000±n/a nM
Citation
 Rosowsky, A; Forsch, RA; Bader, H; Freisheim, JH Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain. J Med Chem 34:1447-54 (1991) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50011889
Synonyms:
5-Amino-2-{4-[(2,4-diamino-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | CHEMBL287532
Type:
Small organic molecule
Emp. Form.:
C20H24N8O3
Mol. Mass.:
424.4564
SMILES:
NCCCC(NC(=O)c1ccc(NCc2cnc3nc(N)nc(N)c3c2)cc1)C(O)=O
Structure:
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