Affinity DataKi: 0nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0.00400nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0.00500nMAssay Description:Compound was evaluated for the inhibition of Dihydrofolate reductase at concentration ranged from 0.15-0.50 uMMore data for this Ligand-Target Pair
Affinity DataKi: 0.0340nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
Affinity DataKi: 0.0770nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of human DHFRMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 47nMAssay Description:In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 65nMAssay Description:In vitro inhibition of mouse GAR transformylaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 67nMAssay Description:Binding affinity of the compound towards Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 172nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 189nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 190nMAssay Description:In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Binding affinity of the compound as Competitive substrate in the presence of 50 gmM aminopterin towards recombinant Human Folyl-polyglutamate synthas...More data for this Ligand-Target Pair
Affinity DataKi: 205nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 280nMAssay Description:Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cellsMore data for this Ligand-Target Pair
Affinity DataKi: 336nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 530nMAssay Description:Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Inhibition of RFC-mediated [3H]MTX influx into human CCRF-CEM cellsMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 2.00E+3nMAssay Description:Binding affinity of the compound towards Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 2.30E+3nMAssay Description:Binding affinity of the compound towards Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 3.20E+3nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 3.70E+3nMAssay Description:In vitro inhibition of glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 5.70E+3nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 2.20E+4nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.80E+4nMAssay Description:Compound was tested for the inhibition of recombinant mouse thymidylate synthase, competitive with 5,10-methylenetetrahydrofolate as variable substra...More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 4.30E+4nMAssay Description:Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase.More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 4.50E+4nMAssay Description:Inhibition of Folyl-polyglutamate synthase from mouse liverMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 5.90E+4nMAssay Description:Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase.More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 1.10E+5nMAssay Description:Binding affinity of the compound as Competitive substrate in the presence of 50 gmM aminopterin towards recombinant Human Folyl-polyglutamate synthas...More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 1.15E+5nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 1.36E+5nMAssay Description:Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase.More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 1.85E+5nMAssay Description:Inhibition of Folyl-polyglutamate synthase from mouse liverMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 1.88E+5nMAssay Description:Inhibition of Folyl-polyglutamate synthase from mouse liverMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 1.98E+5nMAssay Description:Compound was evaluated for the binding affinity to mouse liver folyl polyglutamate synthetase.More data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 5.70E+5nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 2.00E+6nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0570nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0970nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Affinity DataIC50: 0.170nMpH: 7.4 T: 2°CAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:Inhibitory concentration against dihydrofolate reductase of Mycobacterium aviumMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Dihydrofolate reductase was assayed with no inhibitor and with a series of concentrations of inhibitors to allow for a range of inhibition from 10 to...More data for this Ligand-Target Pair