Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM242558
Substrate
n/a
Meas. Tech.
ChEMBL_1712015 (CHEMBL4122064)
IC50
18±n/a nM
Citation
 Hamada, M; Takayama, T; Shibata, T; Hiratate, A; Takahashi, M; Yashiro, M; Takayama, N; Okumura-Kitajima, L; Koretsune, H; Kajiyama, H; Naruse, T; Kato, S; Takano, H; Kakinuma, H Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia. Bioorg Med Chem Lett 28:1725-1730 (2018) [PubMed]  Article 
Target
Name:
Egl nine homolog 1
Synonyms:
EGLN1_RAT | Egln1 | Hypoxia-inducible factor (HIF-PH2)
Type:
Enzyme
Mol. Mass.:
36098.74
Organism:
Rattus norvegicus (Rat)
Description:
P59722
Residue:
338
Sequence:
PRAQPAPAQPRVAPPPGGAPGAARAGGAARRGDSSTAASRVPGPEDATQAGSGPGPAEPSSEDPPPSRSPGPERASLCPAGGGPGEALSPSGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGRETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCSGKLGNYRINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELKPNSVSKDV
  
Inhibitor
Name:
BDBM242558
Synonyms:
US9422240, 1-353
Type:
Small organic molecule
Emp. Form.:
C20H18ClN3O6
Mol. Mass.:
431.826
SMILES:
OC(=O)CNC(=O)C1=C(O)CCN(Cc2ccc(Oc3ccc(Cl)cc3)nc2)C1=O |c:7|
Structure:
Search PDB for entries with ligand similarity: