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Target
Diacylglycerol O-acyltransferase 1
Ligand
BDBM50272088
Substrate
n/a
Meas. Tech.
ChEMBL_1712182 (CHEMBL4122231)
EC50
20±n/a nM
Citation
 Yu, T; Wu, C; Shih, N; Li, Q; Chan, C; Pan, H; Yao, D; Pan, Y; Liang, W; Shen, L; Zhao, H; Li, J; Chen, S Discovery of dimethyl pent-4-ynoic acid derivatives, as potent and orally bioavailable DGAT1 inhibitors that suppress body weight in diet-induced mouse obesity model. Bioorg Med Chem Lett 28:1686-1692 (2018) [PubMed]  Article 
Target
Name:
Diacylglycerol O-acyltransferase 1
Synonyms:
ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:
Protein
Mol. Mass.:
55297.82
Organism:
Homo sapiens (Human)
Description:
O75907
Residue:
488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA
  
Inhibitor
Name:
BDBM50272088
Synonyms:
CHEMBL4126883
Type:
Small organic molecule
Emp. Form.:
C22H26N4O3
Mol. Mass.:
394.4668
SMILES:
CC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)N1CCOc2ncnc(N)c2C1=O |r,wU:7.10,wD:4.3,(41.23,-28.2,;39.91,-28.98,;38.58,-28.22,;39.91,-30.51,;38.59,-31.28,;37.25,-30.52,;35.91,-31.3,;35.94,-32.83,;37.27,-33.6,;38.59,-32.82,;34.61,-33.61,;34.61,-35.16,;33.27,-35.93,;31.95,-35.16,;31.95,-33.62,;33.27,-32.84,;30.62,-35.93,;30.73,-37.45,;29.6,-38.51,;28.08,-38.29,;27.31,-36.95,;25.8,-37.19,;24.84,-35.99,;25.4,-34.56,;26.91,-34.33,;27.48,-32.89,;27.87,-35.52,;29.34,-35.06,;29.57,-33.54,)|
Structure:
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