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Target
Carboxypeptidase N catalytic chain
Ligand
BDBM50275212
Substrate
n/a
Meas. Tech.
ChEMBL_1714517 (CHEMBL4124566)
IC50
>380000±n/a nM
Citation
 Itoh, T; Yoshimoto, N; Hirano, Y; Yamamoto, K Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group. Bioorg Med Chem Lett 28:2256-2260 (2018) [PubMed]  Article 
Target
Name:
Carboxypeptidase N catalytic chain
Synonyms:
ACBP | Anaphylatoxin inactivator | Arginine carboxypeptidase | CBPN_HUMAN | CPN | CPN1 | Carboxypeptidase N catalytic chain | Carboxypeptidase N polypeptide 1 | Carboxypeptidase N small subunit | Carboxypeptidase N, catalytic subunit | Kininase-1 | Lysine carboxypeptidase | Plasma carboxypeptidase B | SCPN | Serum carboxypeptidase N
Type:
PROTEIN
Mol. Mass.:
52293.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1496379
Residue:
458
Sequence:
MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA
  
Inhibitor
Name:
BDBM50275212
Synonyms:
CHEMBL4127473
Type:
Small organic molecule
Emp. Form.:
C12H15ClN2O3Se
Mol. Mass.:
349.67
SMILES:
[#6]-[#6]-[#6](=O)[Se;v2][#6]-[#6](-[#6]-c1cnc(-[#7])c(Cl)c1)-[#6](-[#8])=O
Structure:
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