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Target
Eukaryotic initiation factor 4A-III
Ligand
BDBM50283442
Substrate
n/a
Meas. Tech.
ChEMBL_1725518 (CHEMBL4140796)
IC50
290±n/a nM
Citation
 Mizojiri, R; Nakata, D; Satoh, Y; Morishita, D; Shibata, S; Iwatani-Yoshihara, M; Kosugi, Y; Kosaka, M; Takeda, J; Sasaki, S; Takami, K; Fukuda, K; Kamaura, M; Sasaki, S; Arai, R; Cary, DR; Imaeda, Y Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1 ACS Med Chem Lett 8:1077-1082 (2017) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-III
Synonyms:
ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DDX48 | DEAD box protein 48 | EIF4A3 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | IF4A3_HUMAN | KIAA0111 | NMP 265 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | hNMP 265
Type:
Protein
Mol. Mass.:
46871.02
Organism:
Homo sapiens (Human)
Description:
P38919
Residue:
411
Sequence:
MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
  
Inhibitor
Name:
BDBM50283442
Synonyms:
CHEMBL4172770
Type:
Small organic molecule
Emp. Form.:
C29H22Cl3N3O3
Mol. Mass.:
566.862
SMILES:
Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1c[nH]c(=O)c(c1)-c1cccc(Cl)c1
Structure:
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