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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50016641
Substrate
n/a
Meas. Tech.
ChEBML_157077
IC50
580±n/a nM
Citation
 Rizzi, JP; Schnur, RC; Hutson, NJ; Kraus, KG; Kelbaugh, PR Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors. J Med Chem 32:1208-13 (1989) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Human
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM50016641
Synonyms:
5-(5-Chloro-2-methanesulfonyl-3-trifluoromethyl-phenyl)-imidazolidine-2,4-dione | CHEMBL440790
Type:
Small organic molecule
Emp. Form.:
C11H8ClF3N2O4S
Mol. Mass.:
356.705
SMILES:
CS(=O)(=O)c1c(cc(Cl)cc1C(F)(F)F)-c1[nH]c(=O)[nH]c1O
Structure:
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