Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50304343
Substrate
n/a
Meas. Tech.
ChEMBL_1732883 (CHEMBL4148419)
Ki
213±n/a nM
Citation
 Kucwaj-Brysz, K; Kurczab, R; Jastrz?bska-Wi?sek, M; ?es?awska, E; Sata?a, G; Nitek, W; Partyka, A; Siwek, A; Jankowska, A; Weso?owska, A; Kie?-Kononowicz, K; Handzlik, J Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT Eur J Med Chem 147:102-114 (2018) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50304343
Synonyms:
CHEMBL4160262
Type:
Small organic molecule
Emp. Form.:
C24H30ClFN4O4
Mol. Mass.:
492.971
SMILES:
Cl.COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(C2=O)c2ccccc2F)CC1
Structure:
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