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Found 415 with Last Name = 'kucwaj-brysz' and Initial = 'k'
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50318633(3-benzenesulfonyl-8-piperazin-1-ylquinoline | CHEM...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044615(CHEMBL3329435)
Affinity DataKi:  0.530nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM34152(CHEMBL362628 | E-6801)
Affinity DataKi:  0.580nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50415977(CHEMBL1085113)
Affinity DataKi:  0.630nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50019754(IDALOPIRDINE | LU-AE58054)
Affinity DataKi:  0.830nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606660(CHEMBL5220473)
Affinity DataKi:  0.980nMAssay Description:Displacement of [125I]cAMP-tracer from 5-HT6R in human HeLa cells assessed as measuring cAMP level incubated for 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606652(CHEMBL5218527)
Affinity DataKi:  1nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606653(CHEMBL5219333)
Affinity DataKi: <1nMAssay Description:Binding affinity to 5-HT1A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044616(Cerlapirdine | PF-05212365 | SAM-531 | WAY-262531)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM30712(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-clonidine from alpha2-adrenergic receptor in rat brain cortex after 30 mins by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human SERT assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606655(CHEMBL5219924)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to D2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606655(CHEMBL5219924)
Affinity DataKi:  2nMAssay Description:Binding affinity to 5-HT2AR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606656(CHEMBL4117763)
Affinity DataKi:  2nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM21358(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to 5-HT6R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50458523(JNJ-18038683)
Affinity DataKi:  3nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM81790(Amisulpride | CAS_71675-85-9 | NSC_2159 | US101672...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]N-methyl-spiperone from D2R (unknown origin) assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50274767(CHEMBL4125735)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in human HEK293 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM81790(Amisulpride | CAS_71675-85-9 | NSC_2159 | US101672...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]N-methyl-spiperone from D3R (unknown origin) assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50400902(1-(2-(2,4-dimethylphenylsulfanyl)phenyl)piperazine...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity to human 5-HT3R assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50044601(CHEMBL3329445)
Affinity DataKi:  4nMAssay Description:Displacement of LSD from recombinant human 5-HT6R assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50300828(2-(3-(3-fluorophenylsulfonyl)-1H-pyrrolo[2,3-b]pyr...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H] LSD from 5-HT6R in human HeLa cells assessed as inhibition constant incubated for 120 mins in presence of methiothepin by scinti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562615(CHEMBL4764756)
Affinity DataKi:  5.5nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50569820(CHEMBL4860275)
Affinity DataKi:  6nMAssay Description:Binding affinity to human 5-HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50305485(CHEMBL4176950)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50569820(CHEMBL4860275)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50569815(CHEMBL4873623)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50304358(CHEMBL4163778)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in human HEK293 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50304936(CHEMBL4170613)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606657(CHEMBL5219467)
Affinity DataKi:  7nMAssay Description:Displacement of [3H] LSD from recombinant human 5-HT6R expressed in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50304349(CHEMBL4166804)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50305261(CHEMBL589390 | Dimebolin)
Affinity DataKi:  8nMAssay Description:Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cells measured after 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-Raclopride from human dopamine D2L receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606658(CHEMBL5220504)
Affinity DataKi:  9nMAssay Description:Displacement of [3H] LSD from human 5-HT6R expressed in HEK293 cell membrane assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-raclopride from human D2L receptor expressed in human HEK293 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50304624(CHEMBL4174055)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM11638(CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl...)
Affinity DataKi:  9.80nMAssay Description:Binding affinity to D2R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50151315(CHEMBL3769534)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50305286(CHEMBL4170657)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50305484(CHEMBL4168743)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50606655(CHEMBL5219924)
Affinity DataKi:  11nMAssay Description:Binding affinity to alpha2C AR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50516529(CHEMBL4520796)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]LSD from 5-HT6R (unknown origin) expressed in HEK293 cells assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50569828(CHEMBL4876727)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by microbeta counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Ryvu Therapeutics

Curated by ChEMBL
LigandPNGBDBM50562617(CHEMBL4752141)
Affinity DataKi:  11nMAssay Description:ATP-competitive inhibition of recombinant human full-length N-terminal GST-fused MNK2 (1 to 465 residues) expressed in baculovirus expression system ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM50516529(CHEMBL4520796)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-LSD from human 5-HT6R expressed in human HEK293 cells incubated for 1 hr by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM81790(Amisulpride | CAS_71675-85-9 | NSC_2159 | US101672...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

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