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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50451729
Substrate
n/a
Meas. Tech.
ChEMBL_1746140 (CHEMBL4180650)
Ki
17±n/a nM
Citation
 Majekova, M; Ballekova, J; Prnova, M; Stefek, M Structure optimization of tetrahydropyridoindole-based aldose reductase inhibitors improved their efficacy and selectivity. Bioorg Med Chem 25:6353-6360 (2017) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50451729
Synonyms:
CHEMBL4206601
Type:
Small organic molecule
Emp. Form.:
C17H20N2O5
Mol. Mass.:
332.3511
SMILES:
CCOC(=O)N1CCc2c(C1)c1cc(OC)ccc1n2CC(O)=O
Structure:
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