Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM18512
Substrate
n/a
Meas. Tech.
ChEMBL_1747395 (CHEMBL4181905)
IC50
140±n/a nM
Citation
Patel, TS; Bhatt, JD; Vanparia, SF; Patel, UH; Dixit, RB; Chudasama, CJ; Patel, BD; Dixit, BC Ionic liquid mediated stereoselective synthesis of alanine linked hybrid quinazoline-4(3H)-one derivatives perturbing the malarial reductase activity in folate pathway. Bioorg Med Chem 25:6635-6646 (2017) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
21603.71
Organism:
Bos taurus (Cattle)
Description:
P00376
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN