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Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50456584
Substrate
n/a
Meas. Tech.
ChEMBL_1757443 (CHEMBL4192451)
IC50
170±n/a nM
Citation
 Zhang, S; Xu, Z; Gao, C; Ren, QC; Chang, L; Lv, ZS; Feng, LS Triazole derivatives and their anti-tubercular activity. Eur J Med Chem 138:501-513 (2017) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50456584
Synonyms:
CHEMBL4213459
Type:
Small organic molecule
Emp. Form.:
C40H41N5O5
Mol. Mass.:
671.784
SMILES:
OC(=O)c1cc(on1)-c1ccc(OCc2cn(CCCCCCC(=O)Nc3ccc4cc5ccccc5cc4c3)nn2)cc1C1CCCCC1
Structure:
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