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Found 3744 with Last Name = 'chang' and Initial = 'l'
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50059414(2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyri...)
Affinity DataKi:  0.00300nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM85776(CAS_393594 | CHEMBL89852 | MRS1191 | NSC_393594)
Affinity DataKi:  0.0310nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM81811(CAS_123679 | L-657,743 | MK-912 | NSC_123679)
Affinity DataKi:  0.0700nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((+)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [125I]OXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((+)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((+)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50186588(8-cyclopentyl-2,6-diphenyl-9H-purine | CHEMBL20782...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50303852((+)-trans-3-(2-Phenylethyl)-2,3,4,4aalpha,5,6,7,7a...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50303852((+)-trans-3-(2-Phenylethyl)-2,3,4,4aalpha,5,6,7,7a...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]OXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  0.320nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50019492((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Affinity DataKi:  0.360nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50065757((S)-N-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c...)
Affinity DataKi:  0.362nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50065774((R)-N-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c...)
Affinity DataKi:  0.468nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50205280(2,6-diphenyl-8-isobutyl-1-deazapurine | CHEMBL2214...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  0.550nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50065756(CHEMBL317580 | N-(9-Chloro-2-furan-2-yl-[1,2,4]tri...)
Affinity DataKi:  0.586nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50205281(2,6-diphenyl-8-isopropyl-1-deazapurine | CHEMBL221...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(MOUSE)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50019492((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Affinity DataKi:  0.620nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50205286(8-cyclopentyl-2,6-diphenyl-1-deazapurin | CHEMBL21...)
Affinity DataKi:  0.620nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50303848((+)-trans-3-Methyl-2,3,4,4aalpha,5,6,7,7aalpha-oct...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50303848((+)-trans-3-Methyl-2,3,4,4aalpha,5,6,7,7aalpha-oct...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]OXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50053929(CHEMBL88147 | N-(9-Chloro-2-furan-2-yl-[1,2,4]tria...)
Affinity DataKi:  0.650nMAssay Description:Displacement of specific [125I]-AB-MECA binding at human adenosine A3 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50053929(CHEMBL88147 | N-(9-Chloro-2-furan-2-yl-[1,2,4]tria...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity at cloned human adenosine A3 receptor expressed in HEK-293 cells was determined using [125I]-AB-MECA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50186599(8-cyclohexyl-2,6-diphenyl-9H-purine | CHEMBL207529...)
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Taiwan University

LigandPNGBDBM22170((2S)-1-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}pip...)
Affinity DataKi:  0.75nM ΔG°:  -48.4kJ/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50019492((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Affinity DataKi:  0.790nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50186590(8-isopropyl-2,6-diphenyl-9H-purine | CHEMBL204780 ...)
Affinity DataKi:  0.820nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM81811(CAS_123679 | L-657,743 | MK-912 | NSC_123679)
Affinity DataKi:  0.850nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50205285(2,6-diphenyl-8-(1-ethylpropyl)-1-deazapurine | CHE...)
Affinity DataKi:  0.870nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 4(Homo sapiens (Human))
Research And Development Division

Curated by ChEMBL
LigandPNGBDBM50226415(CHEMBL3142312)
Affinity DataKi:  0.880nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM81811(CAS_123679 | L-657,743 | MK-912 | NSC_123679)
Affinity DataKi:  0.890nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Taiwan University

LigandPNGBDBM22199(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2E)-3-...)
Affinity DataKi:  0.900nMAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50205283(2,6-diphenyl-8-cyclohexyl-1-deazapurine | CHEMBL21...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataKi:  0.980nMAssay Description:Binding affinity to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM85522(LY-23728 | LY23728)
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50065775(5-Amino-pentanoic acid (9-chloro-2-furan-2-yl-[1,2...)
Affinity DataKi:  1.13nMAssay Description:Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50065771(4-(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]qui...)
Affinity DataKi:  1.15nMAssay Description:Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50205279(2,6-diphenyl-1-deazapurine | CHEMBL220535)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50020671(13-(2-Amino-ethyl)-19-benzyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50375504(CHEMBL259704)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50053936(4-Amino-N-(9-chloro-2-furan-2-yl-[1,2,4]triazolo[1...)
Affinity DataKi:  1.38nMAssay Description:Binding affinity was determined in radioligand binding assay at rat striatal Adenosine A2A receptor vs [3H]-CGS- 21680More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM442759(6-Chloro-N,1-dimethyl-N-{1-[4-(trifluoromethyl)phe...)
Affinity DataKi:  1.5nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM35256((S)-mianserin | Lerivon | MIANSERIN | MIANSERIN (+...)
Affinity DataKi:  1.58nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM50019492((+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)...)
Affinity DataKi:  1.62nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 4(Homo sapiens (Human))
Research And Development Division

Curated by ChEMBL
LigandPNGBDBM50226410(CHEMBL3142318)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 4(Homo sapiens (Human))
Research And Development Division

Curated by ChEMBL
LigandPNGBDBM50226412(CHEMBL3142332)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Leiden/Amsterdam Center For Drug Research

Curated by ChEMBL
LigandPNGBDBM50375500(CHEMBL259607)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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