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Target
Serine--tRNA ligase
Ligand
BDBM50339906
Substrate
n/a
Meas. Tech.
ChEMBL_1762365 (CHEMBL4197612)
Ki
0.180000±n/a nM
Citation
 Zhang, B; De Graef, S; Nautiyal, M; Pang, L; Gadakh, B; Froeyen, M; Van Mellaert, L; Strelkov, SV; Weeks, SD; Van Aerschot, A Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases. Eur J Med Chem 148:384-396 (2018) [PubMed]  Article 
Target
Name:
Serine--tRNA ligase
Synonyms:
6.1.1.11 | SYS_ECOLI | SerRS | Serine--tRNA ligase | Seryl-tRNA synthetase | Seryl-tRNA(Ser/Sec) synthetase | serS
Type:
PROTEIN
Mol. Mass.:
48404.41
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_117814
Residue:
430
Sequence:
MLDPNLLRNEPDAVAEKLARRGFKLDVDKLGALEERRKVLQVKTENLQAERNSRSKSIGQAKARGEDIEPLRLEVNKLGEELDAAKAELDALQAEIRDIALTIPNLPADEVPVGKDENDNVEVSRWGTPREFDFEVRDHVTLGEMHSGLDFAAAVKLTGSRFVVMKGQIARMHRALSQFMLDLHTEQHGYSENYVPYLVNQDTLYGTGQLPKFAGDLFHTRPLEEEADTSNYALIPTAEVPLTNLVRGEIIDEDDLPIKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVEMVQIVRPEDSMAALEEMTGHAEKVLQLLGLPYRKIILCTGDMGFGACKTYDLEVWIPAQNTYREISSCSNVWDFQARRMQARCRSKSDKKTRLVHTLNGSGLAVGRTLVAVMENYQQADGRIEVPEVLRPYMNGLEYIG
  
Inhibitor
Name:
BDBM50339906
Synonyms:
((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl(S)-2-amino-3-hydroxypropanoylsulfamate | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE | CHEMBL1163070 | SerSA
Type:
Small organic molecule
Emp. Form.:
C13H19N7O8S
Mol. Mass.:
433.397
SMILES:
N[C@@H](CO)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
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