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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50460345
Substrate
n/a
Meas. Tech.
ChEMBL_1769377 (CHEMBL4221489)
IC50
946±n/a nM
Citation
 Varnes, JG; Xiong, H; Forst, JM; Holmquist, CR; Ernst, GE; Frietze, W; Dembofsky, B; Andisik, DW; Palmer, WE; Hinkley, L; Steelman, GB; Wilkins, DE; Tian, G; Jonak, G; Potts, WM; Wang, X; Brugel, TA; Alhambra, C; Wood, MW; Veale, CA; Albert, JS Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1. Bioorg Med Chem Lett 28:1043-1049 (2018) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:
Enzyme
Mol. Mass.:
78270.54
Organism:
Homo sapiens (Human)
Description:
P48067
Residue:
706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50460345
Synonyms:
CHEMBL4224997
Type:
Small organic molecule
Emp. Form.:
C28H34N4O
Mol. Mass.:
442.5958
SMILES:
CN1CC2CCC1(CC2)C(NC(=O)c1c(C)cccc1C)c1cccc(c1)-c1cnn(C)c1 |(27.48,-27.58,;27.48,-26.03,;26.13,-25.26,;26.13,-23.69,;27.48,-22.9,;28.83,-23.69,;28.83,-25.26,;28.22,-23.92,;27.12,-25.03,;30.18,-26.03,;30.18,-27.57,;31.51,-28.34,;32.83,-27.57,;31.51,-29.87,;30.17,-30.63,;28.83,-29.84,;30.17,-32.16,;31.5,-32.93,;32.83,-32.16,;32.82,-30.63,;34.17,-29.84,;31.5,-25.26,;31.5,-23.74,;32.82,-22.97,;34.16,-23.74,;34.16,-25.27,;32.83,-26.04,;35.51,-26.04,;35.67,-27.59,;37.19,-27.92,;37.97,-26.57,;39.52,-26.41,;36.93,-25.41,)|
Structure:
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