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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50460360
Substrate
n/a
Meas. Tech.
ChEMBL_1769377 (CHEMBL4221489)
IC50
1703±n/a nM
Citation
 Varnes, JG; Xiong, H; Forst, JM; Holmquist, CR; Ernst, GE; Frietze, W; Dembofsky, B; Andisik, DW; Palmer, WE; Hinkley, L; Steelman, GB; Wilkins, DE; Tian, G; Jonak, G; Potts, WM; Wang, X; Brugel, TA; Alhambra, C; Wood, MW; Veale, CA; Albert, JS Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1. Bioorg Med Chem Lett 28:1043-1049 (2018) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:
Enzyme
Mol. Mass.:
78270.54
Organism:
Homo sapiens (Human)
Description:
P48067
Residue:
706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50460360
Synonyms:
CHEMBL4229212
Type:
Small organic molecule
Emp. Form.:
C24H26ClF3N2O
Mol. Mass.:
450.924
SMILES:
CN1CC2CCC1(CC2)C(NC(=O)c1cccc(c1Cl)C(F)(F)F)c1ccc(C)cc1 |(7.2,-37.44,;7.2,-35.88,;5.85,-35.11,;5.85,-33.54,;7.2,-32.74,;8.56,-33.54,;8.56,-35.11,;7.94,-33.77,;6.84,-34.88,;9.91,-35.89,;9.91,-37.42,;11.24,-38.2,;12.57,-37.43,;11.24,-39.73,;9.9,-40.49,;9.9,-42.03,;11.23,-42.8,;12.56,-42.03,;12.56,-40.49,;13.89,-39.72,;13.9,-42.79,;15.23,-43.55,;15.23,-42.01,;13.9,-44.33,;11.24,-35.11,;11.23,-33.58,;12.56,-32.82,;13.9,-33.58,;15.25,-32.8,;13.9,-35.12,;12.57,-35.89,)|
Structure:
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