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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50460372
Substrate
n/a
Meas. Tech.
ChEMBL_1769377 (CHEMBL4221489)
IC50
8.0±n/a nM
Citation
 Varnes, JG; Xiong, H; Forst, JM; Holmquist, CR; Ernst, GE; Frietze, W; Dembofsky, B; Andisik, DW; Palmer, WE; Hinkley, L; Steelman, GB; Wilkins, DE; Tian, G; Jonak, G; Potts, WM; Wang, X; Brugel, TA; Alhambra, C; Wood, MW; Veale, CA; Albert, JS Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1. Bioorg Med Chem Lett 28:1043-1049 (2018) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:
Enzyme
Mol. Mass.:
78270.54
Organism:
Homo sapiens (Human)
Description:
P48067
Residue:
706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50460372
Synonyms:
CHEMBL4224738
Type:
Small organic molecule
Emp. Form.:
C22H26ClN3O
Mol. Mass.:
383.914
SMILES:
CN1CC2CCC1(CC2)[C@H](NC(=O)c1c(N)cccc1Cl)c1ccccc1 |r,wU:9.11,(15.37,-15.67,;15.37,-14.14,;14.05,-13.38,;14.05,-11.85,;15.37,-11.06,;16.7,-11.85,;16.7,-13.38,;16.1,-12.07,;15.02,-13.16,;18.02,-14.15,;18.02,-15.69,;19.36,-16.47,;20.69,-15.69,;19.35,-18.01,;18.01,-18.77,;16.69,-18.01,;18.01,-20.32,;19.35,-21.1,;20.69,-20.31,;20.69,-18.77,;22.01,-18.01,;19.36,-13.38,;20.69,-14.15,;22.03,-13.39,;22.03,-11.84,;20.69,-11.06,;19.36,-11.84,)|
Structure:
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