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Target
Sodium- and chloride-dependent glycine transporter 1
Ligand
BDBM50460378
Substrate
n/a
Meas. Tech.
ChEMBL_1769377 (CHEMBL4221489)
IC50
18±n/a nM
Citation
 Varnes, JG; Xiong, H; Forst, JM; Holmquist, CR; Ernst, GE; Frietze, W; Dembofsky, B; Andisik, DW; Palmer, WE; Hinkley, L; Steelman, GB; Wilkins, DE; Tian, G; Jonak, G; Potts, WM; Wang, X; Brugel, TA; Alhambra, C; Wood, MW; Veale, CA; Albert, JS Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1. Bioorg Med Chem Lett 28:1043-1049 (2018) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent glycine transporter 1
Synonyms:
GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:
Enzyme
Mol. Mass.:
78270.54
Organism:
Homo sapiens (Human)
Description:
P48067
Residue:
706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKVWHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTNGSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLEHRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
  
Inhibitor
Name:
BDBM50460378
Synonyms:
CHEMBL4225262
Type:
Small organic molecule
Emp. Form.:
C22H23ClF3N3O
Mol. Mass.:
437.886
SMILES:
CN1CC2CCC1(CC2)C(NC(=O)c1cccc(c1Cl)C(F)(F)F)c1ccncc1 |(5.54,-23.59,;5.54,-22.03,;4.18,-21.26,;4.18,-19.69,;5.54,-18.89,;6.89,-19.69,;6.89,-21.26,;6.28,-19.92,;5.18,-21.03,;8.25,-22.04,;8.25,-23.58,;9.58,-24.35,;10.91,-23.58,;9.58,-25.89,;8.24,-26.65,;8.24,-28.18,;9.57,-28.96,;10.9,-28.18,;10.9,-26.65,;12.23,-25.88,;12.24,-28.94,;13.57,-29.71,;13.57,-28.17,;12.24,-30.49,;9.58,-21.27,;9.57,-19.74,;10.9,-18.97,;12.24,-19.74,;12.24,-21.27,;10.91,-22.04,)|
Structure:
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