Reaction Details Report a problem with these data
Target
Phosphoglycerate mutase 1
Ligand
BDBM50460640
Substrate
n/a
Meas. Tech.
ChEMBL_1769995 (CHEMBL4222107)
IC50
2300±n/a nM
Citation
 Wang, P; Jiang, L; Cao, Y; Zhang, X; Chen, B; Zhang, S; Huang, K; Ye, D; Zhou, L Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation. Bioorg Med Chem 26:1961-1970 (2018) [PubMed]  Article 
Target
Name:
Phosphoglycerate mutase 1
Synonyms:
BPG-dependent PGAM 1 | PGAM-B | PGAM1 | PGAM1_HUMAN | PGAMA | Phosphoglycerate mutase 1 | Phosphoglycerate mutase isozyme B
Type:
PROTEIN
Mol. Mass.:
28806.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109479
Residue:
254
Sequence:
MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK
  
Inhibitor
Name:
BDBM50460640
Synonyms:
ALIZARIN RED | CHEBI:40863
Type:
Small organic molecule
Emp. Form.:
C14H8O7S
Mol. Mass.:
320.274
SMILES:
Oc1c(O)c2C(=O)c3ccccc3C(=O)c2cc1S(O)(=O)=O
Structure:
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