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Found 810 with Last Name = 'huang' and Initial = 'k'
TargetApelin receptor(Homo sapiens (Human))
Huazhong University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50556826(CHEMBL4745863)
Affinity DataKi:  0.220nMAssay Description:Displacement of [Glp65, Nle75, Tyr77][125I]-apelin13 from human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting based rad...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Huazhong University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50556827(CHEMBL4748838)
Affinity DataKi:  0.25nMAssay Description:Displacement of [Glp65, Nle75, Tyr77][125I]-apelin13 from human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting based rad...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Huazhong University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50556825(CHEMBL4787784)
Affinity DataKi:  0.460nMAssay Description:Displacement of [Glp65, Nle75, Tyr77][125I]-apelin13 from human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting based rad...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Huazhong University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50556828(CHEMBL4798771)
Affinity DataKi:  0.600nMAssay Description:Displacement of [Glp65, Nle75, Tyr77][125I]-apelin13 from human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting based rad...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297420((Z)-N-Methyl-2-(naphthalen-1-yloxy)-2-(thiophen-2-...)
Affinity DataKi:  2.01nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297420((Z)-N-Methyl-2-(naphthalen-1-yloxy)-2-(thiophen-2-...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435111(US10584120, Compound 45)
Affinity DataKi:  4nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435105(US10584120, Compound 39)
Affinity DataKi:  4nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435104(US10584120, Compound 38)
Affinity DataKi:  4nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297420((Z)-N-Methyl-2-(naphthalen-1-yloxy)-2-(thiophen-2-...)
Affinity DataKi:  4.16nMAssay Description:Inhibition of [3H]norepinephrine reuptake at norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297420((Z)-N-Methyl-2-(naphthalen-1-yloxy)-2-(thiophen-2-...)
Affinity DataKi:  4.16nMAssay Description:Inhibition of [3H]norepinephrine reuptake at norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435108(US10584120, Compound 42)
Affinity DataKi:  5nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  5.07nMAssay Description:Inhibition of [3H]dopamine reuptake at dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApelin receptor(Homo sapiens (Human))
Huazhong University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50556824(CHEMBL4746142)
Affinity DataKi:  5.10nMAssay Description:Displacement of [Glp65, Nle75, Tyr77][125I]-apelin13 from human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting based rad...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataKi:  5.11nMAssay Description:Inhibition of [3H]norepinephrine reuptake at norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetApelin receptor(Homo sapiens (Human))
Huazhong University Of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50556829(CHEMBL4743589)
Affinity DataKi:  5.60nMAssay Description:Displacement of [Glp65, Nle75, Tyr77][125I]-apelin13 from human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting based rad...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435128(US10584120, Compound 62)
Affinity DataKi:  6nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435114(US10584120, Compound 47)
Affinity DataKi:  6nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435123(US10584120, Compound 56)
Affinity DataKi:  7nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435126(US10584120, Compound 60)
Affinity DataKi:  7nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297418((E)-N-Methyl-2-(naphthalen-1-yloxy)-2-(thiophen-2-...)
Affinity DataKi:  7.47nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297418((E)-N-Methyl-2-(naphthalen-1-yloxy)-2-(thiophen-2-...)
Affinity DataKi:  7.47nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataKi:  7.57nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435112(US10584120, Compound 46)
Affinity DataKi:  8nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435109(US10584120, Compound 43)
Affinity DataKi:  8nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435106(US10584120, Compound 40)
Affinity DataKi:  9nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435116(US10584120, Compound 49)
Affinity DataKi:  10nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435115(US10584120, Compound 48)
Affinity DataKi:  10nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435110(US10584120, Compound 44)
Affinity DataKi:  10nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435129(US10584120, Compound 63)
Affinity DataKi:  11nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435107(US10584120, Compound 41)
Affinity DataKi:  12nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435130(US10584120, Compound 64)
Affinity DataKi:  13nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435117(US10584120, Compound 50)
Affinity DataKi:  13nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435078(US10584120, Compound 9)
Affinity DataKi:  16nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435127(US10584120, Compound 61)
Affinity DataKi:  16nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435103(US10584120, Compound 37)
Affinity DataKi:  18nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435125(US10584120, Compound 59)
Affinity DataKi:  19nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435131(US10584120, Compound 65)
Affinity DataKi:  20nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435075(US10584120, Compound 7)
Affinity DataKi:  21nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435121(US10584120, Compound 54)
Affinity DataKi:  23nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435118(US10584120, Compound 51)
Affinity DataKi:  24nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297421(CHEMBL558525 | N-methyl-1-((1R,2R)-2-(naphthalen-1...)
Affinity DataKi:  27.8nMAssay Description:Inhibition of [3H]norepinephrine reuptake at norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297421(CHEMBL558525 | N-methyl-1-((1R,2R)-2-(naphthalen-1...)
Affinity DataKi:  30.4nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435102(US10584120, Compound 36)
Affinity DataKi:  32nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Oregon State University

Curated by ChEMBL
LigandPNGBDBM50297419(CHEMBL558065 | N-methyl-1-((1S,2R)-2-(naphthalen-1...)
Affinity DataKi:  33.2nMAssay Description:Inhibition of [3H]serotonin reuptake at serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435090(US10584120, Compound 21)
Affinity DataKi:  36nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435097(US10584120, Compound 28)
Affinity DataKi:  39nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435076(US10584120, Compound 8)
Affinity DataKi:  49nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435072(US10584120, Compound 1)
Affinity DataKi:  53nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminyl-peptide cyclotransferase(Homo sapiens (Human))
National Health Research Institutes

US Patent
LigandPNGBDBM435089(US10584120, Compound 20)
Affinity DataKi:  57nMAssay Description:An inhibition activity assay of QC inhibitors was conducted. See Huang et al., J. Biol. Chem. 2011, 286, 12439-12449. A reaction mixture containing 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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