Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50454088
Substrate
n/a
Meas. Tech.
ChEMBL_1775582 (CHEMBL4232574)
Ki
4450±n/a nM
Citation
 Mujumdar, P; Bua, S; Supuran, CT; Peat, TS; Poulsen, SA Synthesis, structure and bioactivity of primary sulfamate-containing natural products. Bioorg Med Chem Lett 28:3009-3013 (2018) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Homo sapiens (Human)
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM50454088
Synonyms:
5''-O-(Sulfamoyl)Adenosine | 5''-O-Sulfamoyladenosine | CHEMBL471144
Type:
Small organic molecule
Emp. Form.:
C10H14N6O6S
Mol. Mass.:
346.32
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COS(N)(=O)=O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: