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Target
Proteasome subunit beta type-1
Ligand
BDBM50462603
Substrate
n/a
Meas. Tech.
ChEMBL_1776080 (CHEMBL4233072)
IC50
13±n/a nM
Citation
 Lei, M; Feng, H; Bai, E; Zhou, H; Wang, J; Shi, J; Wang, X; Hu, S; Liu, Z; Zhu, Y Design, synthesis, in vitro and in vivo evaluation, and structure-activity relationship (SAR) discussion of novel dipeptidyl boronic acid proteasome inhibitors as orally available anti-cancer agents for the treatment of multiple myeloma and mechanism studies. Bioorg Med Chem 26:3975-3981 (2018) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-1
Synonyms:
PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5
Type:
PROTEIN
Mol. Mass.:
26493.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1366691
Residue:
241
Sequence:
MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD
  
Inhibitor
Name:
BDBM50462603
Synonyms:
CHEMBL4248209 | US11542283, Compound V-8A
Type:
Small organic molecule
Emp. Form.:
C20H30BCl2N3O5
Mol. Mass.:
474.186
SMILES:
COC[C@H](NC(=O)c1cc(Cl)ccc1Cl)C(=O)N[C@@H](CC(C)C)B1OCCNCCO1 |r|
Structure:
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