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Found 403 with Last Name = 'bai' and Initial = 'e'
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL
LigandPNGBDBM50039655(5,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL684...)
Affinity DataKi:  14nMAssay Description:Inhibition of PDGF-stimulated autophosphorylation of PDGF-receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50229939(CHEMBL423481)
Affinity DataIC50:  0.460nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042631((E)-(3R,5S)-7-[5-(4-Fluoro-phenyl)-2-isopropyl-4-p...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042625((E)-(3R,5S)-7-[2,4-Bis-(4-fluoro-phenyl)-5-isoprop...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042607((E)-(3R,5S)-7-[4,5-Bis-(4-fluoro-phenyl)-2-isoprop...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042614(CHEMBL120932 | Sodium; 7-[4,5-bis-(4-fluoro-phenyl...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50281061((1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octano...)
Affinity DataIC50:  2nMAssay Description:Tested in vitro for the inhibition of Squalene synthase activity, measured using juvenile male rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462606(CHEMBL4249022)
Affinity DataIC50:  2nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042620((E)-(3R,5S)-7-[5-(4-Fluoro-phenyl)-2-isopropyl-4-(...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042615((E)-(3R,5S)-7-[4-(4-Chloro-3,5-dimethyl-phenyl)-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50229940(CHEMBL286248)
Affinity DataIC50:  2.30nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462612(CHEMBL4246480)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing Normal University

Curated by ChEMBL
LigandPNGBDBM50267307(CHEMBL4085842)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant cytoplasmic GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042629(CHEMBL121309 | Sodium; 7-[3-(4-fluoro-phenyl)-5-is...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50037287((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50037287((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042622((E)-(3R,5S)-7-[5-(4-Fluoro-phenyl)-2-isopropyl-4-(...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042601(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing Normal University

Curated by ChEMBL
LigandPNGBDBM50267306(CHEMBL4096021)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human recombinant cytoplasmic GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462622(CHEMBL4238198)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462613(CHEMBL4246864)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50281068((1S,3S,4S,5R,6R,7R)-1-((4R,5S)-3,4-Dihydroxy-5-met...)
Affinity DataIC50:  4nMAssay Description:Tested in vitro for the inhibition of Squalene synthase activity, measured using juvenile male rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042612(CHEMBL121610 | Sodium; 7-[5-(4-fluoro-2-methyl-phe...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462611(CHEMBL4241473)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462620(CHEMBL4251272)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037286((1S,3S,4S,5R,6R,7R)-1-((4R,5S)-4-Acetoxy-5-methyl-...)
Affinity DataIC50:  5nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50037285((1S,3S,4S,5R,6R,7R)-6-((E)-(4S,6S)-4,6-Dimethyl-oc...)
Affinity DataIC50:  5nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50281062((1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octano...)
Affinity DataIC50:  5nMAssay Description:Tested in vitro for the inhibition of Squalene synthase activity, measured using juvenile male rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50037285((1S,3S,4S,5R,6R,7R)-6-((E)-(4S,6S)-4,6-Dimethyl-oc...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Squalene synthase activity in juvenile male rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042611(CHEMBL333003 | Sodium; 3,5-dihydroxy-7-[6-hydroxy-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462605(CHEMBL4245244)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataIC50:  5.56nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataIC50:  5.60nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462619(CHEMBL4238378)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
Hospital Regional Universitario

Curated by ChEMBL
LigandPNGBDBM50604669(CHEMBL5208485)
Affinity DataIC50:  6.30nMAssay Description:Positive allosteric modulator activity at GLP-1R in rat INS1 beta-cells assessed potentiation of GLP-1(7-36)NH2 induced insulin secretion at 0.1 nM i...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462603(CHEMBL4248209 | US11542283, Compound V-8A)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037287((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  7nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Glaxo Research And Development

Curated by ChEMBL
LigandPNGBDBM50037287((1S,3S,4S,5R,6R,7R)-1-((4S,5S)-4-Acetoxy-3,5-dimet...)
Affinity DataIC50:  7nMAssay Description:Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042616((E)-(3R,5S)-7-[2-tert-Butyl-4,5-bis-(4-fluoro-phen...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataIC50:  7nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50229943(CHEMBL27388)
Affinity DataIC50:  7.40nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50398609(CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...)
Affinity DataIC50:  7.70nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50037279((1S,3S,4S,5R,6R,7R)-6-((4R,6S)-4,6-Dimethyl-octano...)
Affinity DataIC50:  8nMAssay Description:Inhibition of juvenile male rat liver microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Florida Atlantic University

Curated by ChEMBL
LigandPNGBDBM16596(4-N,6-N-bis[(4-fluoro-3-methylphenyl)methyl]pyrimi...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50042643((E)-(3R,5S)-7-[5-(3-Chloro-phenyl)-4-(4-fluoro-phe...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against washed rat liver microsomal HMG-CoA reductase (HMGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462604(CHEMBL4242666)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462625(CHEMBL4243375 | US11542283, Compound IV-8)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462621(CHEMBL1813256 | MLN-9708 | US11542283, Compound ML...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing Normal University

Curated by ChEMBL
LigandPNGBDBM50267291(CHEMBL4098967)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of human recombinant cytoplasmic GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Nanjing Forestry University

Curated by ChEMBL
LigandPNGBDBM50462610(CHEMBL4249503)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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