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Target
Tyrosine-protein phosphatase non-receptor type 12
Ligand
BDBM50242014
Substrate
n/a
Meas. Tech.
ChEMBL_1782405 (CHEMBL4253922)
IC50
>100000±n/a nM
Citation
 Mascarello, A; Orbem Menegatti, AC; Calcaterra, A; Martins, PGA; Chiaradia-Delatorre, LD; D'Acquarica, I; Ferrari, F; Pau, V; Sanna, A; De Logu, A; Botta, M; Botta, B; Terenzi, H; Mori, M Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B. Eur J Med Chem 144:277-288 (2018) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 12
Synonyms:
PTN12_HUMAN | PTP-PEST | PTPG1 | PTPN12 | Protein-tyrosine phosphatase G1 | Tyrosine-protein phosphatase non-receptor type 12 | Tyrosine-protein phosphatase non-receptor type 12 (PTP-PEST)
Type:
Protein
Mol. Mass.:
88089.78
Organism:
Homo sapiens (Human)
Description:
Q05209
Residue:
780
Sequence:
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT
  
Inhibitor
Name:
BDBM50242014
Synonyms:
CHEMBL464006 | Morusin | Morusin, 3 | TCMDC-124149 | cid_5281671
Type:
Small organic molecule
Emp. Form.:
C25H24O6
Mol. Mass.:
420.4545
SMILES:
[#6]\[#6](-[#6])=[#6]\[#6]-c1c(oc2c3-[#6]=[#6]C([#6])([#6])[#8]-c3cc(-[#8])c2c1=O)-c1ccc(-[#8])cc1-[#8] |c:10|
Structure:
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