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Target
Dihydrofolate reductase
Ligand
BDBM50025008
Substrate
n/a
Meas. Tech.
ChEBML_53612
IC50
34±n/a nM
Citation
 DeGraw, JI; Christie, PH; Tagawa, H; Kisliuk, RL; Gaumont, Y; Schmid, FA; Sirotnak, FM Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin. J Med Chem 29:1056-61 (1986) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50025008
Synonyms:
2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | CHEMBL9973
Type:
Small organic molecule
Emp. Form.:
C22H29N7O5
Mol. Mass.:
471.5096
SMILES:
CCC(CC1CNc2nc(N)nc(N)c2N1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Structure:
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